Tirzepatide titration schedule

The full Tirzepatide titration ladder — 6 steps, what each one is for, the missed-dose window, and what the approved label says about holding.

Labelled product and use

Zepbound injection · once-weekly subcutaneous · adult weight-reduction path

Label source

Zepbound (weekly): US prescribing information, revised 08/2026. Primary source

Brand names

Mounjaro, Zepbound

Approval status

Approved since 2022 (Mounjaro, type 2 diabetes) and 2023 (Zepbound, weight management); an obstructive sleep apnea indication followed in 2024.

What this summary leaves out

The step amounts, timing and missed-dose rules come from the label itself, linked above; this summary does not reproduce them.

Educational use only, never medical advice. No doses.