Pramlintide titration schedule

The full Pramlintide titration ladder — 4 steps, what each one is for, the missed-dose window, and what the approved label says about holding.

Labelled product and use

Symlin injection · before each major meal · type 1 diabetes path

Label source

Symlin (type 1 diabetes schedule): US prescribing information, revised DailyMed SPL v18, 08/2024. Primary source

Brand names

Symlin

Approval status

FDA-approved as Symlin (NDA 021332); Drugs@FDA lists the product as discontinued (retrieved 25 October 2026), and the FDA shortage listing dates the US SymlinPen discontinuation to 27 October 2025. Its label described use as an adjunct to mealtime insulin in patients with type 1 or type 2 diabetes who have failed to achieve adequate glucose control. It carries a boxed warning for severe hypoglycaemia occurring within three hours of injection, particularly in type 1 diabetes.

What this summary leaves out

The step amounts, timing and missed-dose rules come from the label itself, linked above; this summary does not reproduce them.

Educational use only, never medical advice. No doses.