It stopped working after six months. What happened?

Answer

Probably nothing. Flattening between six and twelve months is the published shape of the curve, not a failure of it.

In more detail

In STEP 1, semaglutide 2.4 mg produced its steepest loss in the first twenty weeks, slowed between weeks 20 and 60, and was near flat by week 68 at a mean total of 14.9%. SURMOUNT-1 showed the same S-curve on tirzepatide, reaching a mean of 20.9% on 15 mg with a flattening tail. STEP 5 followed people to two years and found weight still about 15.2% below baseline at week 104 — the plateau held rather than reversed. The curve was always going to flatten; what almost nobody is told is when.

Source

Wilding 2021 (PMID 33567185); Jastreboff 2022 (PMID 35658024); Garvey 2022 (PMID 36216945).

Educational use only, never medical advice. No doses.