Testosterone esters

Status

FDA-approved. Testosterone cypionate and enanthate injections are FDA-approved for testosterone replacement in males with hypogonadism; enanthate is also approved as a subcutaneous autoinjector (Xyosted). Drugs@FDA lists human testosterone propionate products as discontinued (checked 25 October 2026). Transdermal gels and patches contain unesterified testosterone and have their own labels. The esters are oil-based depots, not peptides — included because they sit next to peptides in the same vial-and-syringe world, and the same record-keeping logic applies.

What it is

The primary male sex hormone, formulated as long-chain esters that release slowly from an intramuscular depot. Half-lives differ by ester: cypionate and enanthate are roughly a week, propionate days.

Source

FDA prescribing information (Depo-Testosterone and equivalents)

Sources

• Testosterone cypionate label (DailyMed)