Polynucleotides
Also known as: PN, Plinest, salmon DNA
Status
No approved product. No FDA approval for aesthetic injection in the United States. Regulated as a medical device in parts of Europe and Asia. Anyone with a fish allergy should note the source material.
What it is
Purified DNA fragments injected into skin to improve quality rather than add volume.
What published research measured
Highly purified DNA fragments, usually from salmon or trout milt, injected into the dermis for skin quality rather than volume. Proposed to act through adenosine A2A receptor engagement and by providing nucleotide substrate for fibroblasts. Closely related to PDRN, which is a shorter-chain preparation from the same source material — the two are frequently conflated and the trial literature does not always distinguish them cleanly. Published studies are mostly small and short.
Source
Elghanian R et al. 1997 — Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanopa… · Manning GS. 1978 — The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides · McMaster GK et al. 1977 — Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridin…
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.