Humanin
Status
No approved product. No FDA-approved labeling exists. Not an approved medicine and never tested in a published human trial.
What it is
A mitochondria-derived peptide studied for cell survival signaling.
What published research measured
A short peptide encoded not by nuclear DNA but by the mitochondrial genome — one of the first mitochondrial-derived peptides identified, discovered in surviving neurons from Alzheimer's brain tissue. Observational human work is interesting: circulating humanin declines with age, and higher concentrations have been reported in centenarians and their offspring. The experimental evidence for cytoprotection is cell-culture and rodent work, including models of Alzheimer's disease, ischaemia and diabetes. What was not identified is any published interventional human study of administered humanin, so there is no efficacy, pharmacokinetic or safety data in humans at any dose.
Source
Observational cohort work reporting higher circulating humanin in centenarians and their offspring
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.