hCG / Enclomiphene Restart
Status
FDA-approved. hCG holds FDA-approved labeling for hypogonadotropic hypogonadism in males, prepubertal cryptorchidism and ovulation induction. Enclomiphene is not FDA-approved; it completed phase 3 development without approval. No combination product is approved.
What it is
A community restart pattern pairing a gonadotropin with a SERM.
What published research measured
A restart protocol combining human chorionic gonadotropin, which acts directly at the luteinising hormone receptor on the testis, with enclomiphene, which blocks hypothalamic oestrogen feedback to raise endogenous gonadotropins. The two act at different levels of the same axis, which is the rationale. Both components have meaningful individual literature: hCG holds approvals including hypogonadotropic hypogonadism in males, and enclomiphene has completed phase 3 trials showing it raises testosterone while preserving sperm concentration, though it was not approved. What does not exist is trial evidence for the combination as a recovery protocol after suppression — the published restart literature is largely observational and small, and recovery timelines vary widely between individuals. No blend in this category has been studied as a blend. Trial evidence, where it exists, was generated on single agents given alone; no published study of the combination for interaction, additive adverse effects or altered pharmacokinetics was identified in the sources reviewed for this entry. Two practical consequences follow. A multi-compound vial is a compounded preparation, so the stability of each component in the presence of the others, and over the life of the vial, is generally unstudied. If a reaction occurs, multiple components make it difficult to attribute it to one of them, which is one reason clinical pharmacology usually introduces agents one at a time.
Source
Not tied to a single designated source; see the published research on this molecule
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.