FOXO4-DRI
Also known as: FOXO4 D-retro-inverso peptide, FOXO4 D-retro-inverso
Status
No approved product. No approved product and no controlled human trial. A designed research peptide used in cell and mouse senescence models.
What it is
A D-retro-inverso peptide designed to interfere with the FOXO4–p53 interaction that helps senescent cells survive. The stereochemistry is part of the molecule; it is not the same thing as measuring the FOXO4 gene or protein.
What published research measured
The original work used cell and mouse models of senescence, ageing and chemotoxicity; a later study looked at senescent Leydig cells in aged mice. Inducing cell death is the mechanism, so effects on healthy tissue are the central unanswered question.
Source
Baar MP et al. 2017, Cell — targeted apoptosis of senescent cells Primary source
Sources
Educational use only, never medical advice. No doses.