Fisetin
Status
Dietary supplement (US). Sold as a dietary supplement. Not approved as a medicine and not evaluated by the FDA for treating any condition.
What it is
A plant flavonoid taken in short high-dose bursts to clear senescent cells.
What published research measured
A flavonoid found in strawberries and other plants, identified in a screen of candidate senolytics as the most potent of those tested in cell models. Mouse work reported extended median and maximum lifespan when given late in life. Human trials are small and mostly ongoing, and the intermittent high-dose schedule used in research bears no resemblance to the amount present in food. Oral bioavailability is poor, which is the main open question about whether animal findings transfer at all.
Source
Yousefzadeh MJ et al. 2018 — Fisetin is a senotherapeutic that extends health and lifespan · Kirkland JL et al. 2020 — Senolytic drugs: from discovery to translation · Apak R et al. 2004 — Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing…
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.