Sermorelin vs Ipamorelin
What is the difference between sermorelin and ipamorelin?
Sermorelin has a regulatory history that ipamorelin never had: it was an approved drug product in the United States, used diagnostically and in paediatric growth hormone deficiency, before it was withdrawn from the market commercially rather than for safety. Ipamorelin has never had FDA approval, and no approval elsewhere is listed in this page's sources. Neither has a currently marketed FDA-approved product — sermorelin is largely supplied through compounding, ipamorelin as a product labelled research-use-only — and they act at two different receptors.
Head-to-head evidence
No head-to-head trial of these two exists. Sermorelin's clinical record is diagnostic and paediatric; ipamorelin's is a discontinued program in a completely different indication. There is no shared endpoint to compare.
A common mistake
Quoting sermorelin's former approval as evidence for the use it is actually being sold for today. The approval was for a different purpose in a different population.
Educational use only, never medical advice. No doses.